In order to identify water stress tolerant genotypes, screen water stress tolerance and sensitivity indices, and determine the best indices, the present study was conducted on 19 potato genotypes in split plots and in a completely randomized basic design including two levels of full irrigation and deficit irrigation (50% of the water given in full irrigation) and three replications in 2023 in the greenhouse of Pertikan Bazr Gostar Company (a producer of different classes of potato seeds) located in Minadasht city, Isfahan province, Iran. Based on the number of commercial tubers produced in two conditions of full irrigation and deficit irrigation, water stress tolerance and sensitivity indices including SSI, SI, HM, TOL, MP, YSI, GMP, STI, MRP, YI, REI, and SRI were calculated. The results of the mean comparison showed that the highest number of commercial tubers produced under full irrigation conditions was related to the AD50 genotype and under deficit irrigation conditions was related to the AD15 genotype. The results of the correlation test showed that the MRP index had the highest correlation with yield under both full irrigation and deficit irrigation conditions and was the most appropriate index for screening and finding superior genotypes. According to the various methods used in the present study, such as three-dimensional diagram and cluster analysis, the three genotypes AD15, AD50, and AD2 were introduced as superior genotypes for achieving high yield under deficit conditions. The use of simple and reliable methods to identify superior genotypes under water stress conditions has appropriate efficiency in breeding programs for adaptation to deficit conditions due to its intensification because of climate change.